Research Interests/Things I think are interesting:

The Youtuber nalahamilton.science

nalahamilton.science

Cute txt art

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Sex chromosome specific phenotypes:

Escape genes, Loss of Y chromosome, X chromosome inactivation (see research documents tab)

Evolutionary Game Theory:

Can genomic information be modeled as a game?

Evolutionary game theory and replicator dynamics (video)
Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition (paper)
Dissecting genomic imprinting and genetic conflict from a game theory prospective (paper)
Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer (paper)

Spacial and temporial organization of the nucleus:

Can we define a cell type or differentiation stage by chromatin states?
Waddington epigenetics

Tan, L., Xing, D., Chang, C. H., Li, H., & Xie, X. S. (2018). Three-dimensional genome structures of single diploid human cells. Science. https://doi.org/10.1126/science.aat5641

How is the nucleus involved in cell mobility?

The role of LINC complex and nuclear polarization in migrating fibroblasts

Papers I’m reading/going to read

Fey et al. 2024 (PREPRINT)Directed insulin secretion occurs at precise cortical regions with optimal ELKS content that are devoid of microtubules

Ho et al. 2024 (PREPRINT)Pancreatic islet α cells regulate microtubule stability in neighboring β cells to tune insulin secretion and induce functional heterogeneity in individual mouse and human islets

Contact me

hamiltonnalj@gmail.com